NUDT15 Polyclonal Antibody

Background:
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
NUDT15, MTH2, NUDT15D

Immunogen: Recombinant fusion protein of human NUDT15 (NP_060753.1).

Swissprot: Q9NV35
Gene ID: 55270

Calculated MW: 18 kDa
Observed MW: 19 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.