NuMA rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],function:May be a structural component of the nucleus.,subcellular location:Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident.,

Synonyms: NUMA1, NUMA, Nuclear mitotic apparatus protein 1, NuMA protein, SP-H antigen

Gene Name: NUMA1

Gene ID: 4926

SwissProt ID: Q14980

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.