NUMA1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70547
Background:
The nuclear mitotic apparatus protein (NuMA) is a coiled coil protein involved in the formation and maintenance of the mitotic spindle. NuMA plays a role in chromatin organization during interphase, which influences mammary epithelial differentiation (1,2). During apoptosis, carboxy-terminal cleavage of NuMA may amplify signaling in the cell death pathway (2). NuMA is phosphorylated at numerous sites, with phosphorylation at Ser395 occurring in an ATM/ATR-dependent manner in response to DNA damage (3,4).
Alternative Name:
NUMA
Application Dilution: WB: 1:200 - 1:1000, IHC: 1:50 - 1:100
Specificity: NUMA1 polyclonal antibody detects endogenous levels of NUMA1 protein.
Immunogen:
Recombinant protein of human NUMA1.
MW: ~ 133 kDa
Swis Prot.: Q14980
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The nuclear mitotic apparatus protein (NuMA) is a coiled coil protein involved in the formation and maintenance of the mitotic spindle. NuMA plays a role in chromatin organization during interphase, which influences mammary epithelial differentiation (1,2). During apoptosis, carboxy-terminal cleavage of NuMA may amplify signaling in the cell death pathway (2). NuMA is phosphorylated at numerous sites, with phosphorylation at Ser395 occurring in an ATM/ATR-dependent manner in response to DNA damage (3,4).
Alternative Name:
NUMA
Application Dilution: WB: 1:200 - 1:1000, IHC: 1:50 - 1:100
Specificity: NUMA1 polyclonal antibody detects endogenous levels of NUMA1 protein.
Immunogen:
Recombinant protein of human NUMA1.
MW: ~ 133 kDa
Swis Prot.: Q14980
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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