NUMB polyclonal, anti-human, mouse, rat

Background:
Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR). Mammalian NUMB homologs play a role in the determination of cell fates during development and bind with EPS15, LNX1, and NOTCH1. Conditional mouse mutants with deletion of NUMB in developing sensory ganglia show a reduction in axonal arborization in afferent fibers. Changes in cellular calcium homeostasis influences NUMB-dependent cell fate decisions during development of the nervous system. Chicken NUMB (c-NUMB) protein is localized to the basal cortex of mitotic neuroepithelial cells.

Alternative Name:
h-Numb, c14_5527, C14orf41, FLJ31314, h Numb, h-Numb, Numb, Numb homolog (Drosophila), Numb homolog, Numb protein homolog, NUMB, Protein numb homolog, Protein S171, S171,

Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:100

Specificity: NUMB polyclonal antibody detects endogenous levels of NUMB protein.

Immunogen:
recombinant protein

MW: 71 kDa

Swiss-Prot: P49757(Human) Q9QZS3(Mouse) Q2LC84(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.