NUP153 polyclonal, anti-human

Background:
Nuclear pore complexes (NPCs) are the channels for the bi-directional movement of macromolecules between the nucleus and cytoplasm, and contain more than 100 different subunits. Many of them belong to a family called nucleoporins, which are characterized by the presence of O-linked N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup153 is a peripheral NPC component that is implicated in protein and RNP transport and in the interaction of NPCs with the nuclear lamina. Nup153 contains a unique N-terminal region, a central domain consisting of four to five zinc fingers and a C-terminal region containing about 30 irregularly spaced FXFG repeats. Nup153 is cleaved by caspases during apoptosis. Nup153 interacts wtih TAP, which is essential for mRNA export, and associates with chromatin towards the end of anaphase, in parallel with the inner nuclear membrane protein LAP2. Nup153 is involved in NPC assembly, in anchoring NPCs within the nuclear envelope and in mediating specific nuclear import events.

Alternative Name:
NUP153, 153 kDa nucleoporin, HNUP153, N153, NU153, Nuclear pore complex protein hnup153, Nuclear pore complex protein Nup153, Nucleoporin 153kDa, Nucleoporin Nup153, Nup 153, Nup153,

Application Dilution:
WB:1:500-1:2,000
ICC:1:100-1:500
FC:1:50-1:100

Specificity: NUP153 polyclonal antibody detects endogenous levels of NUP153 protein.

Immunogen:
Recombinant protein

MW: 154 kDa

Swiss-Prot: P49790(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.