NUP98 (clone 3B8-D7-H10), anti-human
€295.00
In stock
SKU
K001411M
Catalog Number: K001411M
Size: 100 μl
Other size: 50 μl
Isotype: Mouse IgG1
Applications: WB, IP
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Size: 100 μl
Other size: 50 μl
Isotype: Mouse IgG1
Applications: WB, IP
Request Manual
Questions? Contact us!
Background:
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Synonyms: ADIR2, NUP196, NUP96
Cellular Location: Nucleoplasmic side Nucleus Nucleus membrane Peripheral membrane protein nuclear pore complex
Immunogen:
Purified recombinant human NUP98 protein fragments expressed in E.coli.
Gene Symbol: NUP98
Gene ID: 4928
Swiss prot: P52948
Calculated MW: 98kDa
Recommended dilution:
WB 1:1000
Purity:
Affinity purification
Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Synonyms: ADIR2, NUP196, NUP96
Cellular Location: Nucleoplasmic side Nucleus Nucleus membrane Peripheral membrane protein nuclear pore complex
Immunogen:
Purified recombinant human NUP98 protein fragments expressed in E.coli.
Gene Symbol: NUP98
Gene ID: 4928
Swiss prot: P52948
Calculated MW: 98kDa
Recommended dilution:
WB 1:1000
Purity:
Affinity purification
Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
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