NUP98 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene. This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. NUP98 is a peripheral nucleoporin located at both the cytoplasmic and nuclear sides of the central channel of the NPC. NUP98 phosphorylation is critical for NPC disassembly at the onset of mitosis. It also plays roles in gene expression, mitotic checkpoint, and pathogenesis. Ligand blot analysis suggested that NUP98 can function as a docking protein for cytosol-mediated docking of import substrates. In addition to that, NUP98 is a target of the vesicular stomatitis virus M protein-mediated inhibition of mRNA nuclear export.

Description:
Rabbit IgG polyclonal antibody for Nuclear pore complex protein Nup98-Nup96 (NUP98) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
96 kDa nucleoporin antibody, 98 kDa nucleoporin antibody, ADAR2 antibody, ADIR2 antibody, GLFG-repeat containing nucleoporin antibody, Nuclear pore complex protein Nup96 antibody, Nuclear pore complex protein Nup98 Nup96 antibody, Nucleoporin 98kD antibody, nucleoporin 98kDa antibody, Nucleoporin Nup96 antibody, Nucleoporin Nup98 antibody, NUP196 antibody, NUP96 antibody, Nup98 antibody, Nup98-Nup96 antibody, NUP98_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human NUP98 recombinant protein (Position: H549-F880). Human NUP98 shares 95% and 94% amino acid (aa) sequence identity with mouse and rat NUP98, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.