Nurr1 polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels, Transcription Factors

Pathway and Disease: Cell Growth and Death, Development and Behavior, Neurodegenerative Disorders, Transcription

Description:
Nuclear receptors and transcription factors play a role in the development and maintenance of neurons that synthesize the neurotransmitter dopamine. The NURR1 gene encodes a 67-kDa member of the steroid-thyroid hormone-retinoid receptor superfamily. The orphan nuclear receptor NURR1 may function as a general coactivator of gene transcription and transcription factor. Mutations in Nurr1 have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophrenia, and maniac depression. Misregulation of Nurr1 may be associated with rheumatoid arthritis.

Alternate Names: Nuclear receptor subfamily 4 group A member 2, Orphan nuclear receptor NURR1, Immediate-early response protein NOT, Transcriptionally-inducible nuclear receptor, NR4A2, NOT, NURR1, TINUR

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P43354

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NURR1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.