OAS1 polyclonal, anti-human

Background:
This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12.

Synonyms: E18/E16,IFI-4,OIAS,OIASI,2'-5'-oligoadenylate synthase 1

Cellular Location: Nucleus Cytoplasm

Immunogen:
A synthetic peptide of human OAS1

Gene Symbol: OAS1

Gene ID: 4938

Swiss prot: P00973

Calculated MW: 46/42kDa

Recommended dilution:
IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.