OAS1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7726
Background:
The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility.
Alternative Name:
(2 5')oligo(A) synthetase 1, (2-5'')oligo(A) synthase 1, 2 5 Oligoadenylate Synthetase 1, 2 5' oligo A synthase 1, 2 5' oligo A synthetase 1, 2 5A synthase 1, 2 5A synthetase 1, 2' 5' oligo A synthetase 1, 2' 5' oligoadenylate synthetase 1 40/46kDa, 2' 5' oligoadenylate synthetase 1, 2' 5' oligoisoadenylate synthetase 1, 2''-5''-oligoadenylate synthase 1, 2'5' oligo A synthetase 1, 2'5' oligoadenylate synthetase 1, 2'5' oligoisoadenylate synthetase 1, 2-5A synthase 1, E18/E16, IFI 4, IFI4, OAS 1, OAS1, OAS1_HUMAN, OIAS, OIASI, p46/p42 OAS,
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: OAS1 polyclonal antibody detects endogenous levels of OAS1 protein.
Immunogen:
Recombinant full length Human OAS1.
MW: ~ 46 kDa
Swis Prot.: P00973
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility.
Alternative Name:
(2 5')oligo(A) synthetase 1, (2-5'')oligo(A) synthase 1, 2 5 Oligoadenylate Synthetase 1, 2 5' oligo A synthase 1, 2 5' oligo A synthetase 1, 2 5A synthase 1, 2 5A synthetase 1, 2' 5' oligo A synthetase 1, 2' 5' oligoadenylate synthetase 1 40/46kDa, 2' 5' oligoadenylate synthetase 1, 2' 5' oligoisoadenylate synthetase 1, 2''-5''-oligoadenylate synthase 1, 2'5' oligo A synthetase 1, 2'5' oligoadenylate synthetase 1, 2'5' oligoisoadenylate synthetase 1, 2-5A synthase 1, E18/E16, IFI 4, IFI4, OAS 1, OAS1, OAS1_HUMAN, OIAS, OIASI, p46/p42 OAS,
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: OAS1 polyclonal antibody detects endogenous levels of OAS1 protein.
Immunogen:
Recombinant full length Human OAS1.
MW: ~ 46 kDa
Swis Prot.: P00973
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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