OAS1 Polyclonal Antibody

Background:
This gene is induced by interferons and encodes a protein that synthesizes 2', 5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
OAS1, E18/E16, IFI-4, OIAS, OIASI

Immunogen: Recombinant fusion protein of human OAS1 (NP_002525.2).

Swissprot: P00973
Gene ID: 4938

Calculated MW: 41 kDa/43 kDa/46 kDa/47 kDa
Observed MW: 40 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.