OAS2 rabbit polyclonal, anti-human, mouse, rat

Backgroud: 2'-5'-oligoadenylate synthetase 2(OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],catalytic activity:Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.,function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.,induction:By interferons.,similarity:Belongs to the 2-5A synthetase family.,subcellular location:Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.,subunit:Homodimer.,

Synonyms: OAS2, 2'-5'-oligoadenylate synthase 2, (2-5')oligo(A) synthase 2, 2-5A synthase 2, p69 OAS / p71 OAS, p69OAS / p71OAS

Gene Name: OAS2

Gene ID: 4939

SwissProt ID: P29728

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.