OASL Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6230a
Background:
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
Other Names:
2'-5'-oligoadenylate synthase-like protein, 2'-5'-OAS-related protein, 2'-5'-OAS-RP, 59 kDa 2'-5'-oligoadenylate synthase-like protein, Thyroid receptor-interacting protein 14, TR-interacting protein 14, TRIP-14, p59 OASL, p59OASL, OASL, TRIP14
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6230a was selected from the C-term region of human OASL . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: OASL
Gene ID: 8638
Primary Accession: Q15646
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
Other Names:
2'-5'-oligoadenylate synthase-like protein, 2'-5'-OAS-related protein, 2'-5'-OAS-RP, 59 kDa 2'-5'-oligoadenylate synthase-like protein, Thyroid receptor-interacting protein 14, TR-interacting protein 14, TRIP-14, p59 OASL, p59OASL, OASL, TRIP14
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6230a was selected from the C-term region of human OASL . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: OASL
Gene ID: 8638
Primary Accession: Q15646
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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