OAT-1 (mouse) polyclonal, anti-mouse, rat

Protein Family: Transporters

Pathway and Disease: Folding, Sorting and Degradation

Description:
The organic anion transporter 1 (OAT-1 or SLC22A6) is localized to the basolateral membrane of renal tubular epithelial cells and plays a critical role in the excretion and detoxification of anionic compounds. OAT-1 functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). OAT-1 mediates the sodium-independant uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV) and many other organic compounds.

Alternate Names: Solute carrier family 22 member 6, Organic anion transporter 1, OAT1, Renal organic anion transporter 1, ROAT1, Novel kidney transcript, NKT, SLC22A6

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: Q8VC69

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of mouse OAT-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 50% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A and immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Naud J et al. 2011. Drug Metabolism and Disposition. 39(8):1363-1369. PMID# 21525170.
[2] Eisner C et al. 2010. Kidney International. 77:519-526. PMID# 20032962.