OAT-1 Peptide
€133.00
In stock
SKU
300115
Protein Family: Transporters
Pathway and Disease: Folding, Sorting and Degradation
Alternate Names: Solute carrier family 22 member 6; Organic anion transporter 1; OAT1; Renal organic anion transporter 1; ROAT1; PAH transporter; PAHT; SLC22A6
Accession No.: Q4U2R8
Description:
The organic anion transporter 1 (OAT-1 or SLC22A6) is localized to the basolateral membrane of renal tubular epithelial cells and plays a critical role in the excretion and detoxification of anionic compounds. OAT-1 functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). OAT-1 mediates the sodium-independant uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV) and many other organic compounds.
Format:
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 250797 is selected from a sequence within the center region of human OAT-1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Pathway and Disease: Folding, Sorting and Degradation
Alternate Names: Solute carrier family 22 member 6; Organic anion transporter 1; OAT1; Renal organic anion transporter 1; ROAT1; PAH transporter; PAHT; SLC22A6
Accession No.: Q4U2R8
Description:
The organic anion transporter 1 (OAT-1 or SLC22A6) is localized to the basolateral membrane of renal tubular epithelial cells and plays a critical role in the excretion and detoxification of anionic compounds. OAT-1 functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). OAT-1 mediates the sodium-independant uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV) and many other organic compounds.
Format:
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 250797 is selected from a sequence within the center region of human OAT-1. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
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