OATP1 (N286) polyclonal, anti-human
€305.00
In stock
SKU
BS3952
Background:
The organic anion transporting polypeptides, OATP-A (also designated OATP1, OATP1A2 and SLC21A3) and OATP-C (also designated OATP2, SLC21A6 and LST1), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C, but not OATP-A, is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. OATP-A is expressed in liver and kidney and helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and is localized to the basolateral hepatocyte membrane.
Alternative Name:
Solute carrier organic anion transporter family member 1A2, OATP-A, Organic anion-transporting polypeptide 1, OATP-1, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, SLCO1A2, OATP, OATP1, OATP1A2, SLC21A3
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: OATP1 (N286) polyclonal antibody detects endogenous levels of OATP1 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 250-300 of Human OATP1.
MW: ~ 76 kDa
Swis Prot.: P46721
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The organic anion transporting polypeptides, OATP-A (also designated OATP1, OATP1A2 and SLC21A3) and OATP-C (also designated OATP2, SLC21A6 and LST1), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C, but not OATP-A, is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. OATP-A is expressed in liver and kidney and helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and is localized to the basolateral hepatocyte membrane.
Alternative Name:
Solute carrier organic anion transporter family member 1A2, OATP-A, Organic anion-transporting polypeptide 1, OATP-1, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, SLCO1A2, OATP, OATP1, OATP1A2, SLC21A3
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: OATP1 (N286) polyclonal antibody detects endogenous levels of OATP1 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 250-300 of Human OATP1.
MW: ~ 76 kDa
Swis Prot.: P46721
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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