OAZ1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61230
Background:
Antizyme 1 (AZ1) negatively regulates polyamine synthesis by enhancing the negative feedback loop controlling ornithine decarboxylase (ODC) activity. Polyamines are involved in cell cycle and cell growth, and thus the interaction between AZ1 and ODC functions in this process as well, in a regulatory manner. Furthermore, treatment of cells with leptomycin B, an inhibitor of chromosomal maintenance proteins, causes the relocation of AZ1 to the nucleus, suggesting a novel function of AZ1 not associated with the proteasome.
Alternative Name:
Ornithine decarboxylase antizyme 1, ODC-Az, OAZ1, OAZ
Application Dilution: WB: 1:500~1:1000
Specificity: OAZ1 polyclonal antibody detects endogenous levels of OAZ1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human OAZ1.
MW: ~ 25 kDa
Swis Prot.: P54368
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Antizyme 1 (AZ1) negatively regulates polyamine synthesis by enhancing the negative feedback loop controlling ornithine decarboxylase (ODC) activity. Polyamines are involved in cell cycle and cell growth, and thus the interaction between AZ1 and ODC functions in this process as well, in a regulatory manner. Furthermore, treatment of cells with leptomycin B, an inhibitor of chromosomal maintenance proteins, causes the relocation of AZ1 to the nucleus, suggesting a novel function of AZ1 not associated with the proteasome.
Alternative Name:
Ornithine decarboxylase antizyme 1, ODC-Az, OAZ1, OAZ
Application Dilution: WB: 1:500~1:1000
Specificity: OAZ1 polyclonal antibody detects endogenous levels of OAZ1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human OAZ1.
MW: ~ 25 kDa
Swis Prot.: P54368
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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