Occludin Polyclonal Antibody

Background:
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.

Research Area: Cancer, Signal Transduction

Synonyms:
OCLN, BLCPMG, PPP1R115, PTORCH1, occludin, Occludin

Immunogen: Recombinant fusion protein of human Occludin (NP_002529.1).

Swissprot: Q16625
Gene ID: 100506658

Calculated MW: 8 kDa/23 kDa/31 kDa/52 kDa/54 kDa/59 kDa
Observed MW: 68 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.