OCT-4 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS70993
Background:
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
Alternative Name:
OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: OCT-4 polyclonal antibody detects endogenous levels of OCT-4 protein.
Immunogen:
A synthetic peptide of human POU5F1.
MW: ~ 39 kDa
Swis Prot.: Q01860
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
Alternative Name:
OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: OCT-4 polyclonal antibody detects endogenous levels of OCT-4 protein.
Immunogen:
A synthetic peptide of human POU5F1.
MW: ~ 39 kDa
Swis Prot.: Q01860
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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