OCT4 Polyclonal Antibody

Background:
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells

Synonyms:
POU5F1, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4

Immunogen: A synthetic peptide of human OCT4

Swissprot: Q01860
Gene ID: 5460

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.