Octamer-binding transcription factor 4, OCT-4 (clone N65), anti-human, mouse
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In stock
SKU
BMA1032
Catalog Number: BMA1032
Size: 100 μg
Isotype: Mouse IgG1
Reactivity: human, mouse
Application(s): WB, ICC
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Size: 100 μg
Isotype: Mouse IgG1
Reactivity: human, mouse
Application(s): WB, ICC
Request Information
Background:
Oct-4 (octamer-binding transcription factor 4) also known as POU5F1 (POU domain, class 5, transcription factor 1) is a homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells.[1]As such, it is frequently used as a marker for undifferentiated cells.A critical amount of Oct3/4 is required to sustain stem cell self-renewal, and up- or downregulation induces divergent developmental programs.[2]It has also been showed that Oct3 has a role in cardiac development in the early mouse embryo.[3]Oct-4 expression must be closely regulated; too much or too little will cause differentiation of the cells.[4]
Immunogen:
Recombinant OCT-4 protein.
Recommended Application:
Western Blot, WB(1:500-1:2, 000); Immunocytochemistry, ICC (1:100)
Product Form: Liquid
Purification: Protein A purified
Storage Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.
Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.
Oct-4 (octamer-binding transcription factor 4) also known as POU5F1 (POU domain, class 5, transcription factor 1) is a homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells.[1]As such, it is frequently used as a marker for undifferentiated cells.A critical amount of Oct3/4 is required to sustain stem cell self-renewal, and up- or downregulation induces divergent developmental programs.[2]It has also been showed that Oct3 has a role in cardiac development in the early mouse embryo.[3]Oct-4 expression must be closely regulated; too much or too little will cause differentiation of the cells.[4]
Immunogen:
Recombinant OCT-4 protein.
Recommended Application:
Western Blot, WB(1:500-1:2, 000); Immunocytochemistry, ICC (1:100)
Product Form: Liquid
Purification: Protein A purified
Storage Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.
Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.
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