OPA1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Description:
Rabbit IgG polyclonal antibody for Dynamin-like 120 kDa protein, mitochondrial (OPA1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Dynamin like 120 kDa protein antibody, Dynamin like 120 kDa protein, mitochondrial antibody, Dynamin-like 120 kDa protein, form S1 antibody, FLJ12460 antibody, Juvenile kjer type optic atrophy antibody, KIAA0567 antibody, KJER type antibody, Large GTP binding protein antibody, largeG antibody, MGM1 antibody, Mitochondrial dynamin like 120 kDa protein antibody, Mitochondrial dynamin like GTPase antibody, NPG antibody, NTG antibody, OAK antibody, OPA 1 antibody, opa1 antibody, OPA1 gene antibody, OPA1_HUMAN antibody, Optic atrophy 1 (autosomal dominant) antibody, OPTIC ATROPHY 1 antibody, Optic atrophy 1 gene protein antibody, Optic atrophy 1 homolog (human) antibody, Optic atrophy protein 1 antibody, Optic atrophy protein 1 homolog antibody,

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human OPA1 (919-955aa EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEA), different from the related mouse and rat sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.