Optineurin polyclonal, anti-human

Quantity: 100 µg

Background:
OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Description:
Rabbit IgG polyclonal antibody for Optineurin (OPTN) detection. Tested with WB, IHC-P in Human.

Synonyms:
14.7K interacting protein antibody, Ag9 C5 antibody, ALS12 antibody, E3 14.7K interacting protein antibody, E3-14.7K-interacting protein antibody, FIP 2 antibody, FIP-2 antibody, FIP2 antibody, Glaucoma 1 open angle E (adult onset) antibody, Glaucoma 1 open angle E antibody, GLC1E antibody, HIP 7 antibody, HIP-7 antibody, HIP7 antibody, Huntingtin interacting protein 7 antibody, Huntingtin interacting protein HYPL antibody, Huntingtin interacting protein L antibody, Huntingtin yeast partner L antibody, Huntingtin-interacting protein 7 antibody, Huntingtin-interacting protein L antibody, HYPL antibody, Injury inducible protein I 55 antibody, NEMO related protein antibody, NEMO-related protein antibody, NRP antibody, Optic neuropathy inducing protein antibody, Optic neuropathy-inducing protein antibody, Optineurin antibody, OPTN antibody, OPTN_HUMAN antibody, TFIIIA IntP antibody, TFIIIA-IntP antibody, Transcription factor IIIA interacting protein antibody, Transcription factor IIIA-interacting protein antibody, Tumor necrosis factor alpha inducible cellular protein containing leucine zipper domains antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Optineurin recombinant protein (Position: R241-I577). Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse and rat Optineurin.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.