OPTN polyclonal, anti-human, mouse

Background:
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Synonyms: ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP

Cellular Location: Cytoplasm Cytoplasmic vesicle Golgi apparatus Recycling endosome autophagosome perinuclear region trans-Golgi network

Immunogen:
Recombinant protein of human OPTN

Gene Symbol: OPTN

Gene ID: 10133

Swiss prot: Q96CV9

Calculated MW: 66kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.