OPTN polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP17993C
Catalog Number: AC-AP17993C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB21453
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB21453
Applications: WB
Datasheet
Request Information
Background:
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Other Names:
Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
Target/Specificity:
This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.
Antigen Region:
71-96
Antigen Type: Synthetic Peptide
Gene Name: OPTN
Gene ID: 10133
Primary Accession: Q96CV9
NCBI Accession: NP_001008212.1;NP_001008213.1;NP_001008214.1;NP_068815.2
Other Accession: Q8R5M4; NP_068815.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Other Names:
Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
Target/Specificity:
This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.
Antigen Region:
71-96
Antigen Type: Synthetic Peptide
Gene Name: OPTN
Gene ID: 10133
Primary Accession: Q96CV9
NCBI Accession: NP_001008212.1;NP_001008213.1;NP_001008214.1;NP_068815.2
Other Accession: Q8R5M4; NP_068815.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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