ORAI1 (clone 6D11A11), anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Immune System, Signal Transduction

Description:
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Alternate Names: ORAI1, Transmembrane protein 142A, TMEM142A, Calcium release-activated calcium channel protein 1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q96D31

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ORAI1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.