Orai1 polyclonal, anti-human, mouse

Background:
Orai1 (ORAI calcium release-activated calcium modulator 1), also known as ORAT1, CRACM1 (calcium release-activated calcium modulator 1) or TMEM142A (transmembrane protein 142A), is a 301 amino acid multi-pass membrane protein that belongs to the Orai family of proteins. Localizing to the plasma membrane, Orai1 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. Specifically, Orai1 functions as a pore subunit of the store-operated calcium release-activated calcium channel (CRAC) and is essential for proper function of the CRAC channel. CRAC channels are responsible for mediating calcium influx in T-cells and play an important role in the immune response. Mutations in the gene encoding Orai1 can result in severe combined immunodeficiency (SCID).

Alternative Name:
ORAI1, CRACM1, TMEM142A, Calcium release activated calcium channel protein 1, Calcium release activated calcium modulator 1, Calcium release-activated calcium channel protein 1, CRACM 1, CRACM1, CRCM1, CRCM1, FLJ14466, Orai 1, ORAI calcium release activated calcium modulator 1, orai1, ORAT1, Protein orai 1, Protein orai-1, TMEM 142A, TMEM142A, Transmembrane protein 142A,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Orai1 polyclonal antibody detects endogenous levels of Orai1 protein.

Immunogen:
Synthetic peptide within mouse Orai1 aa 150-250.

MW: 33 kDa

Swiss-Prot: Q96D31(Human) Q8BWG9(Mouse)

Purification & Purity:
Peptide affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.