ORC2L antibody (clone 3E11-1G5), anti-human
€435.00
In stock
SKU
AC-AT3152a
Catalog Number: AC-AT3152a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IHC, E
Request Information AC-AT3152a">Request Information
Background:
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.
Other Names:
Origin recognition complex subunit 2, ORC2, ORC2L
Antigen Type:
Recombinant Protein
Gene Name: ORC2
Gene ID: 4999
NCBI Accession: NP_006181.1
Primary Accession: Q13416
Other Accession: BC014834
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.
Other Names:
Origin recognition complex subunit 2, ORC2, ORC2L
Antigen Type:
Recombinant Protein
Gene Name: ORC2
Gene ID: 4999
NCBI Accession: NP_006181.1
Primary Accession: Q13416
Other Accession: BC014834
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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