Orexin-A polyclonal, anti-human, mouse, rat

Protein Family: Cytokines

Pathway and Disease: Signaling Molecules and Interaction

Description:
Orexin-A is a neuropeptide that plays a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiological responses of these complementary homeostatic functions. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. Defects in orexin-A are a cause of narcolepsy. Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.

Alternate Names: Orexin, Hypocretin, Hcrt, Orexin-A, Hypocretin-1, Hcrt1, HCRT, OX, PPORX, PPOX

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: O43612

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human orexin-A.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.