Orexin Receptor 1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Orexins are endogeneous peptides that activate Orexin Receptor type 1 and type 2, two closely related G-protein coupled receptors. Orexins-A and -B are hypothalamic peptides derived from a precursor called preproorexin and affect the stimulation of food intake. They act on G protein receptors named orexin receptor-1(OX1R) and orexin receptor-2(OX2R), respectively. Stimulation of these receptors by orexins causes an increase in intracellular calcium levels in hypothalamic cells in vitro. In vivo, orexins control feeding and may also be involved in modulating sleep-wake cycles and other hypothalamic functions.

Description:
Rabbit IgG polyclonal antibody for Orexin receptor type 1 (HCRTR1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
HCRTR 1 antibody, HCRTR1 antibody, Hypocretin receptor type 1 antibody, Orexin receptor type 1 antibody, Ox-1-R antibody, Ox1-R antibody, Ox1r antibody, OX1R_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Orexin Receptor 1(327-342aa FRQASDREAVYACFTF), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human Orexin Receptor 1(327-342aa FRQASDREAVYACFTF), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.