ORP150 polyclonal, anti-human, mouse, rat

Background:
ORP150, also known as HYOU1 (hypoxia upregulated 1), is a 999 amino acid protein that localizes to the lumen of the endoplasmic reticulum (ER) and is a member of the heat shock protein 70 (HSP 70) family. ORP150 is highly expressed in tissues that have well-developed ERs and a large number of secretory proteins (such as liver and pancreas). It is expressed at lower levels in kidney and brain, and plays an essential role in cytoprotective cellular responses to hypoxia (oxygen deprivation). Specifically, ORP150 participates in protein folding and secretion in the ER and functions to protect cells from hypoxia-induced apoptosis, thereby playing a crucial role in cell survival. ORP150 expression is upregulated in a variety of tumors, such as breast cancer, suggesting an important role in tumorigenesis. The gene encoding ORP150 has two translation initiation sites, resulting in a truncated transcript that lacks an ER signal peptide, but is thought to function as a housekeeping protein in the cytoplasm.

Alternative Name:
ORP-150, GRP-170, HYOU1, GRP170, ORP150, 150 kDa oxygen regulated protein, 150 kDa oxygen-regulated protein, 170 kDa glucose regulated protein, 170 kDa glucose-regulated protein, DKFZp686N08236, FLJ94899, FLJ97572, glucose regulated protein 170, Grp 170, GRP-170, Grp170, HSP 12A, HSP12A, Hyou1, HYOU1, Hypoxia up regulated 1, hypoxia up-regulated 1 precursor, Hypoxia up-regulated protein 1, Hypoxia upregulated 1, Orp 150, ORP-150, Orp150, oxygen regulated protein (150kD),

Application Dilution:
WB:1:5,000-1:20,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: ORP150 polyclonal antibody detects endogenous levels of ORP150 protein.

Immunogen:
Recombinant protein within human ORP150 aa 800-950.

MW: 111 kDa

Swiss-Prot: Q9Y4L1(Human) Q9JKR6(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.