OSR2 (F118) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS9252
Background:
OSR (odd-skipped related) proteins belong to the odd C2H2-type zinc-finger protein family and are involved in embryonic development and bone formation. OSR2 (odd-skipped related 2) is a 312 amino acid protein that contains five zinc-finger domains. It is expressed in the kidneys, skeletal muscle, testis and mouse embryos and may be involved in transcriptional activity and osteoblast function. The expression of OSR2 is regulated by C/EBP regulatory elements. OSR2 plays a role in regulating palatal development and expression of alkaline phosphatase. Two isoforms, OSR2A and OSR2B, are produced due to alternative splicing. OSR2B is 36 amino acids shorter than OSR2A and contains only three zinc-finger motifs. Both isoforms localize to the nucleus and are thought to exhibit opposite transcriptional activities. Mutations in the gene encoding OSR2 can alter the gene expression of Pax-9 and TGFβ3.
Alternative Name:
Protein odd-skipped-related 2
Application Dilution: WB: 1:500~1:1000
Specificity: OSR2 (F118) polyclonal antibody detects endogenous levels of OSR2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 80-136 of Human OSR2.
MW: ~ 36 kDa
Swis Prot.: Q8N2R0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
OSR (odd-skipped related) proteins belong to the odd C2H2-type zinc-finger protein family and are involved in embryonic development and bone formation. OSR2 (odd-skipped related 2) is a 312 amino acid protein that contains five zinc-finger domains. It is expressed in the kidneys, skeletal muscle, testis and mouse embryos and may be involved in transcriptional activity and osteoblast function. The expression of OSR2 is regulated by C/EBP regulatory elements. OSR2 plays a role in regulating palatal development and expression of alkaline phosphatase. Two isoforms, OSR2A and OSR2B, are produced due to alternative splicing. OSR2B is 36 amino acids shorter than OSR2A and contains only three zinc-finger motifs. Both isoforms localize to the nucleus and are thought to exhibit opposite transcriptional activities. Mutations in the gene encoding OSR2 can alter the gene expression of Pax-9 and TGFβ3.
Alternative Name:
Protein odd-skipped-related 2
Application Dilution: WB: 1:500~1:1000
Specificity: OSR2 (F118) polyclonal antibody detects endogenous levels of OSR2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 80-136 of Human OSR2.
MW: ~ 36 kDa
Swis Prot.: Q8N2R0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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