Osteocalcin polyclonal, anti-human

Quantity: 100 µg

Background:
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A. It is mapped to 1q22. Osteocalcin may play a role in the body's metabolic regulation and is pro-osteoblastic, or bone-building. Osteocalcin acts as a hormone in the body, causing beta cellsin the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. It may play a role in male fertility. It is found that picomolar amounts of osteocalcin affected insulin secretion and beta-cell proliferation.

Description:
Rabbit IgG polyclonal antibody for Osteocalcin (BGLAP) detection. Tested with WB, IHC-P in Human.

Synonyms:
BGLAP antibody, BGP antibody, Bone gamma carboxyglutamate gla protein osteocalcin antibody, Bone gamma carboxyglutamate protein antibody, Bone Gla protein antibody, Gamma carboxyglutamic acid containing protein antibody, Gamma-carboxyglutamic acid-containing protein antibody, OC antibody, OSTCN_HUMAN antibody, Osteocalcin antibody, OTTHUMP00000016586 antibody, PMF1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Osteocalcin recombinant protein (Position: Y52-V100). Human Osteocalcin shares 69% and 86% amino acid (aa) sequences identity with mouse and rat Osteocalcin, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.