Osterix polyclonal, anti-human, mouse, rat

Protein Family: Transcription Factors

Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death

Description:
Transcription factor Sp7 (osterix) is a transcriptional activator essential for osteoblast differentiation. Osterix binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. Defects in osterix are the cause of osteogenesis imperfecta type 11 (OI11). OI11 is a connective tissue disorder characterized by bone fragility, low bone mass, recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae.

Alternate Names: OSX, Zinc finger protein osterix, Transcription factor Sp7, SP7

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q8TDD2

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human osterix.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.