OTOP2 polyclonal (Center), anti-human
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In stock
SKU
AC-AP17704C
Catalog Number: AC-AP17704C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37737
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37737
Applications: WB
Datasheet
Request Information
Background:
Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths. Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration. Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia. The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3. These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III). OTOP1 was the first described member of the Otopetrin family. Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal. OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures.
Other Names:
Otopetrin-2, OTOP2
Target/Specificity:
This OTOP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the Central region of human OTOP2.
Antigen Region:
336-363
Antigen Type: Synthetic Peptide
Gene Name: OTOP2 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19657}
Gene ID: 92736
Primary Accession: Q7RTS6
NCBI Accession: NP_835454.1
Other Accession: Q80SX5; NP_835454.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths. Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration. Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia. The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3. These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III). OTOP1 was the first described member of the Otopetrin family. Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal. OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures.
Other Names:
Otopetrin-2, OTOP2
Target/Specificity:
This OTOP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the Central region of human OTOP2.
Antigen Region:
336-363
Antigen Type: Synthetic Peptide
Gene Name: OTOP2 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19657}
Gene ID: 92736
Primary Accession: Q7RTS6
NCBI Accession: NP_835454.1
Other Accession: Q80SX5; NP_835454.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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