P-GlycoProtein(MDR) (clone F4), anti-human

Description: Mouse IgG monoclonal antibody for P-Glycoprotein (MDR), ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1 ) detection. Tested with WB, IHC-P, IHC-F, ICC in Human. No cross reactivity with other proteins.Protein Name: Multidrug resistance protein 1

Protein Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. .

Other Names: Multidrug resistance protein 1A, 3.6.3.44, ATP-binding cassette sub-family B member 1A, MDR1A, Multidrug resistance protein 3, P-glycoprotein 3, Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3

Clone Name(s):
F4

Subcellular Localization: Cell membrane; Multi-pass membrane protein.

Tissue Specificity: ABCB1: Expressed in liver, kidney, small intestineand brain.

Gene ID: 18671

Immunogen: Mixture of human and hamster drug-resistant whole cells and crude plasma membranes.

Calculated MW: 140647

Purification: Ascites

Format: Lyophilized

Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Contents: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Concentration (mg/ml): Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.