p130 Cas (phospho-Y410) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4244
Background:
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
Alternative Name:
Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-p130 Cas (Y410) polyclonal antibody detects endogenous levels of p130 Cas protein only when phosphorylated at Tyr410.
Immunogen:
Synthetic phosphopeptide derived from human p130 Cas around the phosphorylation site of Tyrosine 410.
MW: ~ 130 kDa
Swis Prot.: P56945
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
Alternative Name:
Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-p130 Cas (Y410) polyclonal antibody detects endogenous levels of p130 Cas protein only when phosphorylated at Tyr410.
Immunogen:
Synthetic phosphopeptide derived from human p130 Cas around the phosphorylation site of Tyrosine 410.
MW: ~ 130 kDa
Swis Prot.: P56945
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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