P16 (clone 1E12E10), anti-human, mouse, rat

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Cancers, Cell Growth and Death, Signaling Molecules and Interaction

Description:
CDK4I or p16-INK4 (Cyclin-dependent kinase 4 inhibitor A) is a negative regulator of the proliferation of normal cells. It is interacting strongly with CDK4 and CDK6 and by subsequently inhibiting their interaction with cyclins D and retinoblastoma protein phosphorylation. Defects in p16-INK4 are involved in tumor formation in a wide range of tissues. These defects cause cutaneous malignant melanoma 2 (CMM2), familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, melanoma-astrocytoma syndrome and Li-Fraumeni syndrome.

Alternate Names: P16, Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, cyclin-dependent kinase inhibitor A, CDK4I, p16-INK4a, p16INK4A, p16-INK4, multiple tumor suppressor 1, MTS-1, CDKN2A, CDKN2, MTS1

Application Notes: E: 1:10000; WB: 1:500-1:2000; IHC: 1:200-1:1000

Accession No.: P42771

Antigen: Purified recombinant fragment of P16 expressed in E. coli.

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.