p16-INK4a (clone IMD-16), anti-human

Protein Family: Transcription Factors

Pathway and Disease: Cell Growth and Death, Cancers

Description:
Cyclin-dependent kinase inhibitor 2A (CDKN2A or p16-INK4a) acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclin D and to phosphorylate the retinoblastoma protein.

Alternate Names: Cyclin-dependent kinase inhibitor 2A, isoforms 1/2, Cyclin-dependent kinase 4 inhibitor A, CDK4I, p16-INK4a, p16-INK4, Cdkn2a, P16ink4a

Application Notes: E: 1:5000-1:20000; WB: 1:1000-1:2000; IHC: 1:500-1:1000; ICC: 1:500-1:1000

Accession No.: P51480

Antigen: Recombinant human p16-INK4a.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSA with 0.09% sodium azide. Antibody was purified by anti-mouse IgG affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.