p19 INK4d Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

Research Area: Cancer,Cell Biology,Epigenetics and Nuclear Signaling

Synonyms:
CDK inhibitor p19INK4d, CDKN2D, Cyclin dependent kinase inhibitor 2D, Cyclin-dependent kinase 4 inhibitor D, Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4), inhibitor of cyclin-dependent kinase 4d, INK4D, MGC109660, MGC137547, MGC73010, p19, p19-INK4D, p19INK4d, Similar to cyclin-dependent kinase inhibitor 2D

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse p19 INK4d

Swissprot: P55273,Q60773

Calculated MW: 19 kDa
Observed MW: 19 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 2.6 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.