p19ARF polyclonal, anti-human, mouse, rat

Protein Family: Protein Kinases, Transcription Factors

Pathway and Disease: Cell Growth and Death, Cancers, Infectious Diseases

Description:
P19ARF (Cyclin-dependent kinase inhibitor 2A) induces cell cycle arret in G1 and G2 phases. p19ARF binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestration in the nucleolus. p19ARF also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.

Alternate Names: Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, CDK4I, p16-INK4a, p16-INK4, Cdkn2a, P16ink4a, p14ARF, p19ARF, MLM, CDKN2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q64364

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse p19ARF.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.