p21 (Acetyl Lys154) Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity| preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.|induction:By p53| mezerein (antileukemic compound) and interferon beta.|PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.|Belongs to the CDI family.|tissue specificity:Expressed in all adult human tissues| with 5-fold lower levels observed in the brain.|

Research Area: Cancer, Cell biology, Epigenetics and nuclear signaling, Signal transduction

Synonyms: p21 , Acetyl Lys154, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year