p21 polyclonal, anti-human

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Signal Transduction, Cell Growth and Death, Cancers, Infectious Diseases

Description:
Cyclin-dependent kinase inhibitor 1 (p21) is an important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. P21 binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. p21 functions in the nuclear localization and assembly of the cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, p21 inhibits the kinase activity of the cyclin D-CDK4 complex.

Alternate Names: P21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6

Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000; IHC: 1:50-1:200

Accession No.: P38936

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human p21.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.