p21 polyclonal, anti-human, mouse, rat, dog

Protein Family: Transcription Factors

Pathway and Disease: Cell Growth and Death, Cancers, Infectious Diseases

Description:
Cyclin-dependent kinase inhibitor 1 (p21 or WAF1) is an important intermediate by which TP53/p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. P21 binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

Alternate Names: Cyclin-dependent kinase inhibitor 1, p21, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, CDKN1A, WAF1, CIP1, p21/WAF1/CIP1, CAP20, CDKN1, PIC1, SDI1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P38936

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human p21.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.