p27 polyclonal, anti-human, mouse, rat, dog, pig , bovine, chicken, monkey

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Cell Growth and Death, Signal Transduction, Cancers, Infectious Diseases

Description:
Cyclin-dependent kinase inhibitor p27 (p27) is a regulator of cell cycle progression. p27 is involved in G1 arrest. P27 is a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. P27 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. P27 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4). Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.

Alternate Names: p27, Kip1, p27/kip1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P46527

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human p27.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.