p27Kip1 Blocking Peptide (Center S83)

Background:
This gene encodes a cyclin-dependent kinase inhibitor,which shares a limited similarity with CDK inhibitor CDKN1A/p21.The encoded protein binds to and prevents the activation of cyclinE-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycleprogression at G1. The degradation of this protein, which istriggered by its CDK dependent phosphorylation and subsequentubiquitination by SCF complexes, is required for the cellulartransition from quiescence to the proliferative state. [provided byRefSeq].

Other Names:
Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1

Target/Specificity:
The synthetic peptide sequence is selected from aa 78-90 of HUMAN CDKN1B

Gene Name: CDKN1B {ECO:0000303|PubMed:20824794}

Gene ID: 1027
Primary Accession: P46527
Other Accession: NP_004055.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.