p27Kip1 (clone IMD-27), anti-human, mouse, rat

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Signaling Molecules and Interaction, Cancers, Transcription, Cell Growth and Death, Infectious Diseases

Description:
Cyclin-dependent kinase inhibitor p27 (p27Kip1) is regulator of cell cycle progression. p27Kip1 is involved in G1 arrest, and is a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. P27Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4). Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid.

Alternate Names: p27Kip1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, CDKN1B, KIP1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; ICC: 1:100-1:500

Accession No.: P46527

Antigen: Recombinant rodent p27Kip1 protein.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.