P2RX4 polyclonal, anti-human

Quantity: 100 µg

Background:
Purinoceptor P2X4, also called P2X4R is a protein that in humans is encoded by the P2RX4 gene. This gene belongs to the family of purinoceptors for ATP. P2RX4 was mapped to 12q24.32 by fluorescence in situ hybridization. P2RX4 is a receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. P2X4 receptor in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactile allodynia in normal animals. P2X4 recetors have beeb implicated in the regulation of cardiac function, ATP-mediated cell death, synaptic strengthening, and activating of the inflammasome in response to injury.

Description:
Rabbit IgG polyclonal antibody for P2X purinoceptor 4 (P2RX4) detection. Tested with WB in Human.

Synonyms:
AI504491 antibody, ATP gated cation channel protein antibody, ATP receptor antibody, AW555605 antibody, D5Ertd444e antibody, MGC143034 antibody, OTTMUSP00000023741 antibody, OTTMUSP00000023745 antibody, OTTMUSP00000023746 antibody, OTTMUSP00000023747 antibody, p2rx4 antibody, P2RX4_HUMAN antibody, P2X purinoceptor 4 antibody, P2X receptor subunit 4 antibody, P2X4 antibody, P2X4R antibody, Purinergic receptor antibody, Purinergic receptor P2X ligand gated ion channel 4 antibody, Purinergic receptor P2X4 antibody, Purinoceptor P2X4 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human P2RX4 recombinant protein (Position: N262-Q388). Human P2RX4 shares 91% and 90% amino acid (aa) sequence identity with mouse and rat P2RX4, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.