P2Y4 rabbit polyclonal, anti-human, mouse, rat

Backgroud: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008],function:Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.,PTM:Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Pancreas.,

Synonyms: P2RY4, NRU, P2Y purinoceptor 4, P2Y4, P2P, Uridine nucleotide receptor, UNR

Gene Name: P2RY4

Gene ID: 5030

SwissProt ID: P51582

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.