P300 (EP300) Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP1080b
Background:
EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CBP can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
Other Names:
Histone acetyltransferase p300, p300 HAT, E1A-associated protein p300, EP300, P300
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1080b was selected from the C-term region of human EP300. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EP300 {ECO:0000303|PubMed:15706485, ECO:0000312|HGNC:HGNC:3373}
Gene ID: 2033
Primary Accession: Q09472
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CBP can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
Other Names:
Histone acetyltransferase p300, p300 HAT, E1A-associated protein p300, EP300, P300
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1080b was selected from the C-term region of human EP300. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EP300 {ECO:0000303|PubMed:15706485, ECO:0000312|HGNC:HGNC:3373}
Gene ID: 2033
Primary Accession: Q09472
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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